![]() Overexpression of survivin in various cellular systems was clearly associated with inhibition of cell death, and, conversely, targeting survivin function and/or expression, especially in tumor cells, caused spontaneous cell death and enhanced the effect of other apoptotic stimuli ( Altieri, 2003). Soon after its discovery, there was uncertainty as to the true function(s) of survivin in mammalian cells. Most likely, orthologs of survivin are found in lower organisms, such as yeast, worms and flies, underscoring the evolutionary conservation of this pathway in cellular homeostasis. Survivin ( Uren et al., 2000) and BRUCE ( Ren et al., 2005), another single-baculovirus IAP repeat IAP protein, are the only two essential members of this gene family, in that their homozygous deletion in mice results in early embryonic lethality, and is incompatible with tissue viability ( Okada et al., 2004). These post-translational mechanisms have been largely implicated in survivin protein stability, and in controlling protein trafficking among various subcellular compartments. One example involves stimulation with insulin growth factor-1, which results in stabilization and rapid translation of a pool of survivin mRNA, in a pathway dependent on the mammalian target of rapamycin ( Vaira et al., 2007 Oh et al., 2008).Ī newly generated survivin protein is post-translationally regulated by degradative ( Zhao et al., 2000) and non-degradative cycles ( Vong et al., 2005) of ubiquitylation and de-ubiquitylation, as well as multiple phosphorylation events by kinases, including Cdk1 ( O'Connor et al., 2002), Aurora B ( Wheatley et al., 2007) and protein kinase A ( Dohi et al., 2007). There are also mechanisms of post-transcriptional modulation of survivin levels, especially in tumor cells. Examples of survivin gene expression independent of cell cycle periodicity have also been described, especially in response to growth factor and cytokine stimulation ( Aoki et al., 2003). Located at the tip of chromosome 17 in humans (17q25), a single survivin gene is extensively alternatively spliced to generate several protein isoforms ( Sampath and Pelus, 2007), and is transcriptionally controlled in a sharp cell cycle-dependent manner, with peak expression at mitosis ( Altieri, 2006 Lens et al., 2006). The regulation of the survivin gene is complex, involving multiple pathways of transcriptional and post-transcriptional control. Survivin is a structural homodimer, containing a single baculovirus IAP repeat, which is the hallmark of all IAPs, and a -COOH terminus coiled coil ( Verdecia et al., 2000), with no other identifiable protein domain(s) ( Srinivasula and Ashwell, 2008). Since the cloning of the survivin gene in 1997, there has been mounting interest in the biology and functions of this pathway in several areas of biomedical research, and peer-reviewed publications dealing with various facets of survivin biology have continued to appear at an exponential rate. We do not currently handle any long term rental options in the area.Survivin is the smallest member of the inhibitor of apoptosis (IAP) gene family in mammalian cells ( Srinivasula and Ashwell, 2008). We are primarily a short term vacation rental company.We cannot allow guests to go over capacity at any of our properties.If there is an issue with the dates of your stay or the property a reservationist will contact you. We will send you a rental agreement to fill out to finish confirming your reservation. When you book online your reservation will become active in our system.To get the most accurate pricing, enter the exact dates for your stay and then on the property listing pages you will see the total price listed with all taxes and fees.Winter full week rentals begin on either Friday or Sunday. Winter Rentals – Most homes have a two night minimum stay, except during the December Holiday Vacation week and the February school vacation week where homes rent for a full week.Off Water Homes – Homes rent for a two night minimum stay.We do have a few properties that are Friday to Friday rentals as well. Mooselookmeguntic Lake, Quimby Pond, Dodge Pond, Loon Lake, Saddleback Lake and Beaver Mountain Lake mostly rent Sunday to Sunday. Rangeley Lake and Gull pond homes mostly rent Saturday to Saturday. Summer Rentals – Private waterfront homes are week long stays only in July and August.For summer rentals it is especially important to put in the correct arrival and departure days for the body of water you want to be on or you may not see all of your options. ![]() ![]() ![]() ![]() To ensure that you receive correct search results please read through the following helpful hints. ![]()
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